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What Are the Side Effects of Acid Reflux Medications?

What Are the Side Effects of Acid Reflux Medications?

Proton Pump Inhibitors

Proton pump inhibitors work by blocking acid before it is produced allowing the esophagus to heal.  Proton pump inhibitors are usually well tolerated by most and include such brand names as Losec, Prilosec, and Prevacid.  Adverse side effects are mild. Though several have been reported, common side effects can include headache, rash, abdominal pain, nausea, constipation, and diarrhea. [“Proton pump inhibitors” Drugs.com]

Prolonged use of proton pump inhibitors, defined as being prescribed more than three 14-day treatment courses within one year, has been linked to an increased risk of fractures of the hip, wrist, and spine. [“Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors.” U S Food and Drug Administration]

Histamine H2 Receptor Antagonists

Histamine H2 Receptor Antagonists, more commonly known as H2-blockers, work by reducing the amount of acid the stomach produces.  H2-blockers are usually well tolerated by most and include such brand names as Tagamet, Pepcid AC, and Zantac. Adverse side effects are mild. Though several have been reported, common side effects can include headache, dizziness, vomiting, nausea, constipation, and diarrhea. [“H2 Blockers.” eMedicinehealth.com]

Acid-Suppressive Medication and Pneumonia

According to the Canadian Medical Association Journal, acid-suppressive medication, specifically proton pump inhibitors and histamineH2 receptor antagonists, increase the risk of contracting pneumonia.  The researchers conducted a systematic review of all of the current literature relating to acid-suppressive medication and pneumonia and found that there seemed to be a direct correlation.  The implications of the findings are important to physicians as a warning about prescribing these medications to at-risk patients.  [Eom, Canadian Medical Association Journal]

 

REFERENCES:

[1]” Proton pump inhibitors” Drugs.com. N.p., n.d. Web. 25 Apr. 2012. <http://www.drugs.com/drug-class/proton-pump-inhibitors.html>.

[2]” FDA Drug Safety Communication: Possible increased a risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors.” U S Food and Drug Administration. N.p., n.d. Web. 25 Apr. 2012. http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm213206.htm

[3]” H2 Blockers.” eMedicinehealth.com. N.p., n.d. Web. 25 Apr. 2012. <www.emedicinehealth.com/script/main/art.asp?articlekey=130184&ref=130197>.

[4]Eom, CS, and et al. “Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis..” Canadian Medical Association Journal 183.3 (2011): 310-19. Print.

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